Structure, absolute configuration, and antidiarrheal activity of a thymol derivative from Ageratina cylindrica.
J Nat Prod
; 77(2): 358-63, 2014 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-24502360
ABSTRACT
The leaves of Ageratina cylindrica afforded a thymol derivative that was characterized by physical and spectroscopical methods as (8S)-8,9-epoxy-6-hydroxy-l0-benzoyloxy-7-oxothymol isobutyrate (1). The absolute configuration of 1 was established as 8S by vibrational circular dichroism spectroscopy in combination with density functional theory calculations and by evaluation of the Flack and Hooft X-ray parameters. Compound 1 showed weak antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites and a high inhibitory effect on hyperpropulsive movement of the small intestine in rats.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timol
/
Ageratina
/
Antidiarreicos
/
Antiprotozoários
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article