Your browser doesn't support javascript.
loading
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Evenäs, Johan; Edfeldt, Fredrik; Lepistö, Matti; Svitacheva, Naila; Synnergren, Anna; Lundquist, Britta; Gränse, Mia; Rönnholm, Anna; Varga, Mikael; Wright, John; Wei, Min; Yue, Sherrie; Wang, Junfeng; Li, Chong; Li, Xuan; Chen, Gang; Liao, Yong; Lv, Gang; Tjörnebo, Ann; Narjes, Frank.
Afiliação
  • Evenäs J; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden. Electronic address: johan.evenas@redglead.com.
  • Edfeldt F; Discovery Science, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Lepistö M; Department of Medicinal Chemistry, Respiratory Inflammation and Autoimmunity Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Svitacheva N; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Synnergren A; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Lundquist B; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Gränse M; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Rönnholm A; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Varga M; Department of Medicinal Chemistry, Respiratory Inflammation and Autoimmunity Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Wright J; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Wei M; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Yue S; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Wang J; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Li C; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Li X; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Chen G; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Liao Y; Department of Medicinal Chemistry, DMPK and Biology, BioDuro, Life Science Park Road Bld 2, Beijing 102206, PR China.
  • Lv G; Discovery Science, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Tjörnebo A; AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden.
  • Narjes F; Department of Medicinal Chemistry, Respiratory Inflammation and Autoimmunity Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. Electronic address: Frank.Narjes@astrazeneca.com.
Bioorg Med Chem Lett ; 24(5): 1315-21, 2014 Mar 01.
Article em En | MEDLINE | ID: mdl-24508129
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Xantina Oxidase / Inibidores Enzimáticos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Xantina Oxidase / Inibidores Enzimáticos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article