Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia.

Mattei, Daniele; Djodari-Irani, Anaïs; Hadar, Ravit; Pelz, Andreas; de Cossío, Lourdes Fernandez; Goetz, Thomas; Matyash, Marina; Kettenmann, Helmut; Winter, Christine; Wolf, Susanne A

Mattei, Daniele; Djodari-Irani, Anaïs; Hadar, Ravit; Pelz, Andreas; de Cossío, Lourdes Fernandez; Goetz, Thomas; Matyash, Marina; Kettenmann, Helmut; Winter, Christine; Wolf, Susanne A.

Afiliação

Mattei D; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany.
Djodari-Irani A; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charité Campus Mitte, 10117 Berlin, Germany.
Hadar R; University Hospital, Clinic for Psychiatry and Psychotherapy, Experimental Psychiatry, 01307 Dresden, Germany.
Pelz A; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany.
de Cossío LF; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany.
Goetz T; University Hospital, Clinic for Psychiatry and Psychotherapy, Experimental Psychiatry, 01307 Dresden, Germany.
Matyash M; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany.
Kettenmann H; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany.
Winter C; University Hospital, Clinic for Psychiatry and Psychotherapy, Experimental Psychiatry, 01307 Dresden, Germany.
Wolf SA; Max-Delbrück-Center of Molecular Medicine, Cellular Neuroscience, 13125 Berlin, Germany. Electronic address: susanne.wolf@mdc-berlin.de.

Brain Behav Immun ; 38: 175-84, 2014 May.

Article em En | MEDLINE | ID: mdl-24509090

Assuntos

Antibacterianos/farmacologia; Microglia/efeitos dos fármacos; Minociclina/farmacologia; Neurogênese/efeitos dos fármacos; Esquizofrenia/fisiopatologia; Filtro Sensorial/efeitos dos fármacos; Animais; Encéfalo/efeitos dos fármacos; Citocinas/biossíntese; Modelos Animais de Doenças; Masculino; Microglia/imunologia; Poli I-C/farmacologia; Ratos; Ratos Wistar; Esquizofrenia/imunologia; Esquizofrenia/metabolismo

Palavras-chave

Animal model; Cytokines; Microglia; Minocycline; Neurogenesis; Neuroinflammation; Poly I:C; Schizophrenia; Sensorimotor gating

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Microglia / Neurogênese / Filtro Sensorial / Minociclina / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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