Histidine rich glycoprotein and cancer: a multi-faceted relationship.
Anticancer Res
; 34(2): 593-603, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24510988
ABSTRACT
A better understanding of the interplay between the tumor environment, the immune system, and hemostatic apparatus is essential to effectively improve cancer treatment. Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a wide array of functions. HRG has the ability to bind multiple ligands thereby modulating immunity, cell adhesion, angiogenesis, and thrombosis. Many of these functions are involved in tumor progression and antitumor response. We outline current data on HRG as an important potential player and as a potential future target for cancer therapy.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article