Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.

Bie, Jianbo; Liu, Shuainan; Zhou, Jie; Xu, Bailing; Shen, Zhufang

Bie, Jianbo; Liu, Shuainan; Zhou, Jie; Xu, Bailing; Shen, Zhufang.

Afiliação

Bie J; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu S; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhou J; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xu B; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: xubl@imm.ac.cn.
Shen Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: shenzhf@imm.ac.cn.

Bioorg Med Chem ; 22(6): 1850-62, 2014 Mar 15.

Article em En | MEDLINE | ID: mdl-24530031

Assuntos

Desenho de Fármacos; Inibidores Enzimáticos/farmacologia; Frutose-Bifosfatase/antagonistas & inibidores; Indóis/farmacologia; Regulação Alostérica/efeitos dos fármacos; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Frutose-Bifosfatase/metabolismo; Humanos; Indóis/síntese química; Indóis/química; Estrutura Molecular; Proteínas Recombinantes/metabolismo; Relação Estrutura-Atividade

Palavras-chave

6-Bisphosphatase inhibitor; Allosteric inhibitor; Diabetes; Fructose-1; Indole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Frutose-Bifosfatase / Inibidores Enzimáticos / Indóis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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