Adiponectin polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis.
J Gastroenterol Hepatol
; 29(7): 1396-405, 2014.
Article
em En
| MEDLINE
| ID: mdl-24548122
ABSTRACT
BACKGROUND AND AIM:
The adiponectin polymorphism has been implicated in susceptibility to non-alcoholic fatty liver disease (NAFLD), but the results remain inconclusive. The aim of this meta-analysis is to investigate the association between adiponectin polymorphisms and NAFLD risk.METHODS:
All eligible case-control studies published up to September 2013 were identified by searching PubMed, Web of Science, and CNKI. Effect sizes of odds ratio (OR) and 95% confidence interval (95% CI) were calculated by using a fixed- or random-effect model.RESULTS:
A total of 10 case-control studies were included; of those, there were nine studies (1223 cases and 1580 controls) for +45T>G polymorphism, seven studies (876 cases and 989 controls) for +276G>T polymorphism, and three studies (299 cases and 383 controls) for -11337C>G polymorphism. Overall, a significantly increased risk was found for +45T>G and -11377C>G polymorphism (+45T>G OR = 1.45, 95% CI 1.06-2.00 for recessive model, OR = 1.48, 95% CI 1.07-2.06 for GGâ vsâ TT; -11377C>G OR = 1.52, 95% CI 1.10-2.09 for dominant model, OR = 3.88, 95% CI 1.29-11.68 for GGâ vsâ CC), while for +276G>T polymorphism, we found a significantly decreased risk between them (OR = 0.65, 95% CI 0.45-0.94 for recessive model, OR = 0.58, 95% CI 0.40-0.84 for TTâ vsâ GG). In subgroup analysis by ethnicity, significant association was detected among Asians for +276G>T polymorphism, but not for +45T>G polymorphism. Besides, none of the three adiponectin polymorphisms was associated with the serum adiponectin levels.CONCLUSION:
This meta-analysis suggests that adiponectin +45T>G and -11377C>G polymorphisms might be a risk factor for NAFLD, while +276G>T polymorphism may be a protective factor for NAFLD among Asians.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Predisposição Genética para Doença
/
Adiponectina
/
Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article