Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric acid-induced mesangial cell proliferation.

Zhuang, Yibo; Feng, Quancheng; Ding, Guixia; Zhao, Min; Che, Ruochen; Bai, Mi; Bao, Huaying; Zhang, Aihua; Huang, Songming

Zhuang, Yibo; Feng, Quancheng; Ding, Guixia; Zhao, Min; Che, Ruochen; Bai, Mi; Bao, Huaying; Zhang, Aihua; Huang, Songming.

Afiliação

Zhuang Y; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Feng Q; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Ding G; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and.
Zhao M; Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Che R; Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Bai M; Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Bao H; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and.
Zhang A; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and Institute of Pediatrics, Nanjing Medical University, Nanjing, China.
Huang S; Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China; and Institute of Pediatrics, Nanjing Medical University, Nanjing, China smhuang@njmu.edu.cn.

Am J Physiol Renal Physiol ; 307(4): F396-406, 2014 Aug 15.

Article em En | MEDLINE | ID: mdl-24573389

Assuntos

Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; NADPH Oxidases/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Ácido Úrico/farmacologia; Acetofenonas/farmacologia; Animais; Butadienos/farmacologia; Proliferação de Células/efeitos dos fármacos; Ciclina A2/biossíntese; Ciclina D1/biossíntese; Flavonoides/farmacologia; Células Mesangiais/efeitos dos fármacos; Células Mesangiais/metabolismo; Proteína Quinase 1 Ativada por Mitógeno/antagonistas & inibidores; Proteína Quinase 3 Ativada por Mitógeno/antagonistas & inibidores; NADPH Oxidases/antagonistas & inibidores; Nitrilas/farmacologia; Ratos; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/fisiologia; Receptor 2 Toll-Like/fisiologia; Receptor 4 Toll-Like/fisiologia

Palavras-chave

ERK1/2; cell proliferation; mesangial cells; reactive oxygen species; uric acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Espécies Reativas de Oxigênio / NADPH Oxidases / Proteína Quinase 1 Ativada por Mitógeno / Proteína Quinase 3 Ativada por Mitógeno Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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