Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates.
World J Gastroenterol
; 20(4): 1061-6, 2014 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-24574779
ABSTRACT
AIM:
To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.METHODS:
We retrospectively reviewed H. pylori-infected patients who were treated with a standard triple regimen (PPI, amoxicillin 1 g, and clarithromycin 500 mg, all twice daily for 7 d). The diagnosis of H. pylori infection and its eradication was assessed with the rapid urease test, histological examination by silver staining, or the ¹³C-urea breath test. We divided the patients into two groups one received the standard eradication regimen without PPI pretreatment (Group A), and the other received PPI pretreatment (Group B). The patients in Group B were reclassified into three groups based on the duration of PPI pretreatment Group B-I (3-14 d), Group B-II (15-55 d), and Group B-III (≥ 56 d).RESULTS:
A total of 1090 patients were analyzed and the overall eradication rate was 80.9%. The cure rate in Group B (81.2%, 420/517) was not significantly different from that in Group A (79.2%, 454/573). The eradication rates in Group B-I, B-II and B-III were 80.1% (117/146), 81.8% (224/274) and 81.4% (79/97), respectively.CONCLUSION:
PPI pretreatment did not affect H. pylori eradication rate, regardless of the medication period.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
/
Infecções por Helicobacter
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Inibidores da Bomba de Prótons
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article