Bayesian joint detection-estimation of cerebral vasoreactivity from ASL fMRI data.
Med Image Comput Comput Assist Interv
; 16(Pt 2): 616-24, 2013.
Article
em En
| MEDLINE
| ID: mdl-24579192
ABSTRACT
Although the study of cerebral vasoreactivity using fMRI is mainly conducted through the BOLD fMRI modality, owing to its relatively high signal-to-noise ratio (SNR), ASL fMRI provides a more interpretable measure of cerebral vasoreactivity than BOLD fMRI. Still, ASL suffers from a low SNR and is hampered by a large amount of physiological noise. The current contribution aims at improving the recovery of the vasoreactive component from the ASL signal. To this end, a Bayesian hierarchical model is proposed, enabling the recovery of perfusion levels as well as fitting their dynamics. On a single-subject ASL real data set involving perfusion changes induced by hypercapnia, the approach is compared with a classical GLM-based analysis. A better goodness-of-fit is achieved, especially in the transitions between baseline and hypercapnia periods. Also, perfusion levels are recovered with higher sensitivity and show a better contrast between gray- and white matter.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Encéfalo
/
Mapeamento Encefálico
/
Reconhecimento Automatizado de Padrão
/
Imageamento por Ressonância Magnética
/
Interpretação de Imagem Assistida por Computador
/
Circulação Cerebrovascular
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article