[Effect of drug interaction between clopidogrel and omeprazole in hospital readmision of patients by a recurrent acute coronary syndrome: a case-control study]. / Efecto de la interacción clopidogrel-omeprazol en el reingreso hospitalario de pacientes por recidiva de síndrome coronario agudo: estudio de casos y controles.
Aten Primaria
; 46(8): 426-32, 2014 Oct.
Article
em Es
| MEDLINE
| ID: mdl-24581893
ABSTRACT
OBJECTIVE:
To evaluate the effect of drug interaction between omeprazol and clopidogrel in hospital readmission of patients with acute coronary syndrome (ACS).DESIGN:
Case-control study. LOCATION University Clinic LeonXIII, Medellin, Colombia.PARTICIPANTS:
We selected from a prevalent population, between 2009-2010, use of clopidogrel patients on an outpatient basis (less than one year and more than 30days), and hospital stay for ACS or the presence of a previous ACS. MAINMEASURES:
A case-patient was defined as one who had a recurrence of ACS and a patient-control is defined as one that no recurrence of ACS. Both groups used ambulatory prior clopidogrel due to ACS. As defined risk factor the joint use of omeprazole and clopidogrel outpatients.RESULTS:
During the study, 1680patients clopidogrel formulated. This group identified 50cases readmitted with ACS and 76controls. No statistically significant association was found between use of clopidogrel-omeprazole and increased risk of hospital readmission for ACS (OR 1.05; 95%CI 0.516-2.152; P=.8851).CONCLUSIONS:
In this small group of patients with previous SCA, the simultaneous use of clopidogrel with omeprazole does not increase the risk of a readmission by recurrence of this type of coronary event.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Readmissão do Paciente
/
Omeprazol
/
Ticlopidina
/
Inibidores da Agregação Plaquetária
/
Síndrome Coronariana Aguda
/
Inibidores da Bomba de Prótons
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Ano de publicação:
2014
Tipo de documento:
Article