Lack of interleukin-1&#945; in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice.

Olteanu, Sarita; Kandel-Kfir, Michal; Shaish, Aviv; Almog, Tal; Shemesh, Shay; Barshack, Iris; Apte, Ron N; Harats, Dror; Kamari, Yehuda

Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice.

Olteanu, Sarita; Kandel-Kfir, Michal; Shaish, Aviv; Almog, Tal; Shemesh, Shay; Barshack, Iris; Apte, Ron N; Harats, Dror; Kamari, Yehuda.

Afiliação

Olteanu S; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.
Kandel-Kfir M; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.
Shaish A; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.
Almog T; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.
Shemesh S; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.
Barshack I; Pathology Department, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Apte RN; Department of Microbiology and Immunology, Ben Gurion University, Beer Sheva, Israel.
Harats D; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Kamari Y; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: yehuda.kamari@sheba.health.gov.il.

Dig Liver Dis ; 46(5): 433-9, 2014 May.

Article em En | MEDLINE | ID: mdl-24582082

Assuntos

Colesterol/metabolismo; Fígado Gorduroso/metabolismo; Hepatite/sangue; Hipercolesterolemia/metabolismo; Interleucina-1alfa/deficiência; Células de Kupffer/metabolismo; Triglicerídeos/metabolismo; Alanina Transaminase/sangue; Animais; Dieta Aterogênica; Fígado Gorduroso/genética; Fígado Gorduroso/patologia; Feminino; Expressão Gênica; Hepatite/genética; Hepatite/patologia; Hipercolesterolemia/genética; Interleucina-1alfa/genética; Interleucina-1beta/deficiência; Interleucina-1beta/genética; Interleucina-6/genética; Masculino; Camundongos; Camundongos Knockout; Sistema Porta; RNA Mensageiro/metabolismo; Receptores Tipo I de Interleucina-1/deficiência; Receptores Tipo I de Interleucina-1/genética; Proteína Amiloide A Sérica/genética; Fator de Necrose Tumoral alfa/genética; Vasculite/metabolismo

Palavras-chave

Cytokine; Fatty liver; IL-1; Inflammation; Kupffer cells; NASH

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Colesterol / Interleucina-1alfa / Fígado Gorduroso / Hepatite / Hipercolesterolemia / Células de Kupffer Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google