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The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Siu, Tony; Kumarasinghe, Sathyajith E; Altman, Michael D; Katcher, Matthew; Northrup, Alan; White, Catherine; Rosenstein, Craig; Mathur, Anjili; Xu, Lin; Chan, Grace; Bachman, Eric; Bouthillette, Melaney; Dinsmore, Christopher J; Marshall, C Gary; Young, Jonathan R.
Afiliação
  • Siu T; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: tony_siu@merck.com.
  • Kumarasinghe SE; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Altman MD; Department of Structural Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Katcher M; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Northrup A; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • White C; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Rosenstein C; Department of In Vitro Sciences, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Mathur A; Department of Pharmacology, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Xu L; Department of Drug Metabolism, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Chan G; Department of In Vitro Sciences, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Bachman E; Department of Pharmacology, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Bouthillette M; Department of Basic Pharmaceutical Sciences, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Dinsmore CJ; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Marshall CG; Department of Oncology, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Young JR; Department of Medicinal Chemistry, Merck & Co., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
Bioorg Med Chem Lett ; 24(6): 1466-71, 2014 Mar 15.
Article em En | MEDLINE | ID: mdl-24582987
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Sulfonamidas / Inibidores de Proteínas Quinases / Janus Quinase 2 Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Sulfonamidas / Inibidores de Proteínas Quinases / Janus Quinase 2 Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article