Microvascular glycocalyx dimension estimated by automated SDF imaging is not related to cardiovascular disease.
Microcirculation
; 21(6): 499-505, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24589155
ABSTRACT
OBJECTIVE:
The EG regulates vascular homeostasis and has anti-atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.METHODS:
Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low (<10%) or high risk (≥ 10%) of CVD according to the Framingham algorithm.RESULTS:
In total 120 patients and 30 healthy volunteers were included. Patients had a mean age of 59 ± 14 years, 71 (59%) were men and 24 (20%) were black. Healthy volunteers were on average 28 ± 4 years and 19 (63%) were men. EG dimension was similar in healthy volunteers (2.04 ± 0.23 µm), low-risk patients (2.05 ± 0.24 µm, n = 39), high-risk patients (2.05 ± 0.23 µm, n = 30) and in patients with CVD (2.09 ± 0.21 µm, n = 51, p = 0.79). EG dimension was not correlated with cardiovascular risk factors.CONCLUSIONS:
Microcirculatory EG dimension, as estimated by automated SDF imaging, is not associated with CVD, suggesting that this technique may not contribute to cardiovascular risk stratification.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Glicocálix
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Microcirculação
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Soalho Bucal
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article