Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer.
Chin J Cancer
; 33(3): 133-9, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24589183
ABSTRACT
This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Células da Medula Óssea
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Células Híbridas
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Metástase Neoplásica
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article