Antiangiogenic activity of hypoxylonol C.
J Nat Prod
; 77(4): 1065-8, 2014 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-24593182
ABSTRACT
Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Angiogênese
/
Fluorenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article