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Intrinsically disordered proteins and intrinsically disordered protein regions.
Oldfield, Christopher J; Dunker, A Keith.
Afiliação
  • Oldfield CJ; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202; email: cjoldfie@iupui.edu , kedunker@iupui.edu.
Annu Rev Biochem ; 83: 553-84, 2014.
Article em En | MEDLINE | ID: mdl-24606139
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet they exhibit biological activities. Their mobile flexibility and structural instability are encoded by their amino acid sequences. They recognize proteins, nucleic acids, and other types of partners; they accelerate interactions and chemical reactions between bound partners; and they help accommodate posttranslational modifications, alternative splicing, protein fusions, and insertions or deletions. Overall, IDP-associated biological activities complement those of structured proteins. Recently, there has been an explosion of studies on IDP regions and their functions, yet the discovery and investigation of these proteins have a long, mostly ignored history. Along with recent discoveries, we present several early examples and the mechanisms by which IDPs contribute to function, which we hope will encourage comprehensive discussion of IDPs and IDP regions in biochemistry textbooks. Finally, we propose future directions for IDP research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Intrinsicamente Desordenadas Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Intrinsicamente Desordenadas Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article