Hsp70 and Hsp90 oppositely regulate TGF-ß signaling through CHIP/Stub1.

Shang, Yu; Xu, Xialian; Duan, Xiaolin; Guo, Junwei; Wang, Yinyin; Ren, Fangli; He, Dacheng; Chang, Zhijie

Shang, Yu; Xu, Xialian; Duan, Xiaolin; Guo, Junwei; Wang, Yinyin; Ren, Fangli; He, Dacheng; Chang, Zhijie.

Afiliação

Shang Y; The Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China.
Xu X; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China.
Duan X; The Second People's Hospital of Zhuhai, Guangdong 519000, China.
Guo J; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China.
Wang Y; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China.
Ren F; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China.
He D; The Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Chang Z; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: zhijiec@tsinghua.edu.cn.

Biochem Biophys Res Commun ; 446(1): 387-92, 2014 Mar 28.

Article em En | MEDLINE | ID: mdl-24613385

Assuntos

Proteínas de Choque Térmico HSP70/metabolismo; Proteínas de Choque Térmico HSP90/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Animais; Células COS; Linhagem Celular; Chlorocebus aethiops; Células HEK293; Proteínas de Choque Térmico HSP70/química; Proteínas de Choque Térmico HSP90/química; Humanos; Vison; Complexos Multiproteicos/química; Complexos Multiproteicos/metabolismo; Proteólise; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Transdução de Sinais; Proteína Smad3/química; Proteína Smad3/metabolismo; Ubiquitina-Proteína Ligases/química; Ubiquitinação

Palavras-chave

CHIP/Stub1; Hsp70; Hsp90; Smad3 ubiquitination and degradation; TGF-ß signal

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Proteínas de Choque Térmico HSP90 / Proteínas de Choque Térmico HSP70 / Ubiquitina-Proteína Ligases Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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