Hydrophobic actuation of a DNA origami bilayer structure.
Angew Chem Int Ed Engl
; 53(16): 4236-9, 2014 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-24616083
ABSTRACT
Amphiphilic compounds have a strong tendency to form aggregates in aqueous solutions. It is shown that such aggregation can be utilized to fold cholesterol-modified, single-layered DNA origami structures into sandwich-like bilayer structures, which hide the cholesterol modifications in their interior. The DNA bilayer structures unfold after addition of the surfactant Tweenâ
80, and also in the presence of lipid bilayer membranes, with opening kinetics well described by stretched exponentials. It is also demonstrated that by combination with an appropriate lock and key mechanism, hydrophobic actuation of DNA sandwiches can be made conditional on the presence of an additional molecular input such as a specific DNA sequence.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
DNA
/
Bicamadas Lipídicas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article