Long-term safety and efficacy of second-generation everolimus-eluting stents compared to other limus-eluting stents and bare metal stents in patients with acute coronary syndrome.
Catheter Cardiovasc Interv
; 84(7): 1053-60, 2014 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-24619969
ABSTRACT
OBJECTIVES:
This study aimed to investigate the long-term safety and efficacy of everolimus-eluting stents (EES) compared with other limus-eluting stents and bare metal stents (BMS) in ACS patients.BACKGROUND:
There have been concerns about the long-term safety of drug-eluting stents in the setting of acute coronary syndrome.METHODS:
The study cohort included 1,612 patients presenting with acute coronary syndrome who underwent BMS, SES, E-ZES, or EES implantation. End points included probable or definite stent thrombosis and major adverse cardiovascular events (MACE), defined as a composite of all-cause death, Q-wave myocardial infarction, and target lesion revascularization up to 3 years.RESULTS:
The overall MACE rates were significantly higher for both BMS and SES, but not E-ZES, when compared with EES (EES vs. BMS HR 2.68, 95% CI 1.91-3.78, P <0.001; EES vs. SES HR 1.75, 95% CI 1.24-2.47, P = 0.001 and EES vs. E-ZES HR 1.08, 95% CI 0.65-1.77, P = 0.72). Stent thrombosis rates were similar for EES, E-ZES, and BMS but higher for SES throughout the 3-year follow-up (EES vs. BMS HR 1.02, 95% CI 0.31-3.35, P = 0.973; EES vs. SES HR 4.90, 95% CI 1.75-13.69, P = 0.002 and EES vs. E-ZES HR 1.63, 95% CI 0.37-7.31, P = 0.449).CONCLUSIONS:
There was an improvement in the long-term outcome for MACE with EES when compared to earlier-generation stents, but this was comparable with the 2nd-generation E-ZES. There was no additional risk of early or late stent thrombosis in EES when compared with BMS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sirolimo
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Reestenose Coronária
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Síndrome Coronariana Aguda
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Stents Farmacológicos
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Intervenção Coronária Percutânea
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article