Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches.
Angew Chem Int Ed Engl
; 53(13): 3336-41, 2014 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-24623565
ABSTRACT
General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain "inorganic" amino acids.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Compostos de Tungstênio
/
Técnicas de Síntese em Fase Sólida
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article