Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.

Taddeo, E P; Laker, R C; Breen, D S; Akhtar, Y N; Kenwood, B M; Liao, J A; Zhang, M; Fazakerley, D J; Tomsig, J L; Harris, T E; Keller, S R; Chow, J D; Lynch, K R; Chokki, M; Molkentin, J D; Turner, N; James, D E; Yan, Z; Hoehn, K L

Taddeo, E P; Laker, R C; Breen, D S; Akhtar, Y N; Kenwood, B M; Liao, J A; Zhang, M; Fazakerley, D J; Tomsig, J L; Harris, T E; Keller, S R; Chow, J D; Lynch, K R; Chokki, M; Molkentin, J D; Turner, N; James, D E; Yan, Z; Hoehn, K L.

Afiliação

Taddeo EP; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Laker RC; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Breen DS; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Akhtar YN; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Kenwood BM; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Liao JA; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Zhang M; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Fazakerley DJ; Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.
Tomsig JL; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Harris TE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Keller SR; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Chow JD; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Lynch KR; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Emily Couric Clinical Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.
Chokki M; Teijin Pharma Limited, 4-3-2, Asahigaoka, Hino, Tokyo 191-8512, Japan.
Molkentin JD; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati, OH, USA.
Turner N; Department of Pharmacology, University of New South Wales, Sydney, NSW, Australia.
James DE; Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia ; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW,
Yan Z; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Hoehn KL; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA ; Emily Couric Clinical Cancer

Mol Metab ; 3(2): 124-34, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24634818

Palavras-chave

ANT, adenine nucleotide translocator; BKA, bongkrekic acid; CSA, cyclosporin A; CYPD, cyclophilin D; Cyclophilin D; DAG, diacylglycerol; ETC, electron transport chain; FFA, free fatty acid; Glucose; HFD, high fat diet; HK2, hexokinase 2; Insulin resistance; KO, knockout; LFD, low fat diet; MCAD, medium chain acyl-CoA dehydrogenase; MHC, myosin heavy chain; MIRKO, muscle insulin receptor knockout; MPTP, mitochondrial permeability transition pore; Mitochondrial dysfunction; Mitochondrial permeability transition pore; MnSOD, mitochondrial manganese superoxide dismutase; O2â¢, superoxide; OXPHOS, oxidative phosphorylation; PDH, pyruvate dehydrogenase; PDHa, active PDH; PDHt, total PDH; PM, plasma membrane; Rg', rate of glucose transport; Skeletal muscle; TBARS, thiobarbituric acid reactive substances; TEM, transmission electron microscopy; VDAC, voltage-dependent anion channel; WT, wild type; [3H]-2-DOG, [3H]-2-deoxyglucose; ß-HAD, ß-hydroxyacyl-CoA dehydrogenase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article