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Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C.
Ponziani, Francesca Romana; Viganò, Raffaella; Iemmolo, Rosa Maria; Donato, Maria Francesca; Rendina, Maria; Toniutto, Pierluigi; Pasulo, Luisa; Morelli, Maria Cristina; Burra, Patrizia; Miglioresi, Lucia; Merli, Manuela; Di Paolo, Daniele; Fagiuoli, Stefano; Gasbarrini, Antonio; Pompili, Maurizio; Belli, L; Gerunda, G E; Marino, M; Montalti, R; Di Benedetto, F; De Ruvo, N; Rigamonti, C; Colombo, M; Rossi, G; Di Leo, A; Lupo, L; Memeo, V; Bringiotti, R; Zappimbulso, M; Bitetto, D; Vero, V; Colpani, M; Fornasiere, E; Pinna, A D; Morelli, M C; Bertuzzo, V; De Martin, E; Senzolo, M; Ettorre, G M; Visco-Comandini, U; Antonucci, G; Angelico, M; Tisone, G; Giannelli, V; Giusto, M.
Afiliação
  • Ponziani FR; Agostino Gemelli Hospital, Rome, Italy. Electronic address: francesca.ponziani@yahoo.it.
  • Viganò R; Niguarda Ca' Granda Hospital, Milan, Italy.
  • Iemmolo RM; University of Modena, Modena, Italy.
  • Donato MF; IRCCS Foundation Ca' Granda Maggiore Hospital, Milan, Italy.
  • Rendina M; University of Bari, Bari, Italy.
  • Toniutto P; University of Udine, Udine, Italy.
  • Pasulo L; Ospedali Riuniti, Bergamo, Italy.
  • Morelli MC; Sant'Orsola Malpighi Hospital, Bologna, Italy.
  • Burra P; University of Padua, Padua, Italy.
  • Miglioresi L; San Camillo Spallanzani Hospital, Rome, Italy.
  • Merli M; Sapienza University, Rome, Italy.
  • Di Paolo D; University of Torvergata, Rome, Italy.
  • Fagiuoli S; Ospedali Riuniti, Bergamo, Italy.
  • Gasbarrini A; Agostino Gemelli Hospital, Rome, Italy.
  • Pompili M; Agostino Gemelli Hospital, Rome, Italy.
Dig Liver Dis ; 46(5): 440-5, 2014 May.
Article em En | MEDLINE | ID: mdl-24635906
BACKGROUND: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. AIM: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. METHODS: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. RESULTS: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11±3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p=0.007), treatment duration >80% of the scheduled period (p=0.027), and early virological response (p=0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p=0.008). CONCLUSIONS: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / RNA Viral / Transplante de Fígado / Hepacivirus / Hepatite C Crônica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / RNA Viral / Transplante de Fígado / Hepacivirus / Hepatite C Crônica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article