Prevention of dicarbonyl-mediated advanced glycation by glyoxalases: implication in skin aging.
Biochem Soc Trans
; 42(2): 518-22, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24646271
ABSTRACT
Skin aging is the result of intrinsic chronological aging and photoaging, due to UV exposure, that both share important histological modifications and molecular features, including alterations of proteins. One of the main damage is glycation that occurs when reducing sugars react non-enzymatically with proteins. This reaction also happens when the dicarbonyl compounds GO (glyoxal) and MG (methylglyoxal), which are glucose derivatives, react with proteins. These compounds can be detoxified by the glyoxalase system composed of two enzymes, Glo1 (glyoxalase I) and Glo2 (glyoxalase II). The aims of the present mini-review are to briefly summarize our current knowledge of the biological roles of these enzymes in aging and then discuss the relevance of studying the role of glycation and of detoxifying systems in human skin aging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento da Pele
/
Lactoilglutationa Liase
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article