Determinants for membrane association of the hepatitis C virus NS2 protease domain.
J Virol
; 88(11): 6519-23, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24648458
ABSTRACT
Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is required for HCV polyprotein processing and particle assembly. It comprises an N-terminal membrane domain and a C-terminal, cytosolically oriented protease domain. Here, we demonstrate that the NS2 protease domain itself associates with cellular membranes. A single charged residue in the second α-helix of the NS2 protease domain is required for proper membrane association, NS2 protein stability, and efficient HCV polyprotein processing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Membrana Celular
/
Proteínas não Estruturais Virais
/
Hepacivirus
/
Montagem de Vírus
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article