Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.
Bioorg Med Chem Lett
; 24(8): 1963-7, 2014 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-24656611
ABSTRACT
Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Sesquiterpenos
/
Mitose
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article