Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.

Fan, Xing-Xing; Li, Na; Wu, Jian-Lin; Zhou, Yan-Ling; He, Jian-Xing; Liu, Liang; Leung, Elaine Lai-Han

Fan, Xing-Xing; Li, Na; Wu, Jian-Lin; Zhou, Yan-Ling; He, Jian-Xing; Liu, Liang; Leung, Elaine Lai-Han.

Afiliação

Fan XX; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.
Li N; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.
Wu JL; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.
Zhou YL; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.
He JX; Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, The 1st Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China.
Liu L; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.
Leung EL; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China. lhleung@must.edu.mo.

Molecules ; 19(3): 3508-22, 2014 Mar 21.

Article em En | MEDLINE | ID: mdl-24662070

Assuntos

Apoptose/efeitos dos fármacos; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Caspases/metabolismo; Proteínas de Choque Térmico HSP90/metabolismo; Neoplasias Pulmonares/metabolismo; Transdução de Sinais/efeitos dos fármacos; Triterpenos/farmacologia; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Resistencia a Medicamentos Antineoplásicos; Gefitinibe; Humanos; Concentração Inibidora 50; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Triterpenos Pentacíclicos; Inibidores de Proteínas Quinases/farmacologia; Proteólise/efeitos dos fármacos; Quinazolinas/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Transdução de Sinais / Apoptose / Carcinoma Pulmonar de Células não Pequenas / Proteínas de Choque Térmico HSP90 / Caspases / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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