Enantioselective total synthesis of (-)-walsucochin B.
Org Lett
; 16(7): 1996-9, 2014 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-24670038
ABSTRACT
The first enantioselective total synthesis of the structurally unique nortriterpenoid (-)-walsucochin B has been accomplished through the cationic polyolefin cyclization initiated by chiral epoxide. The core framework and the stereocenters in the natural product were all constructed in this step. A site-selective, late-stage free-radical halogenation and Seyferth-Gilbert homologation was adopted to install the acetylene moiety to synthesize the phenylacetylene. The absolute configuration of walsucochin B was confirmed through enantioselective total synthesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Produtos Biológicos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article