Molecular mechanisms and potentials for differentiating inner ear stem cells into sensory hair cells.
Dev Biol
; 390(2): 93-101, 2014 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-24680894
ABSTRACT
In mammals, hair cells may be damaged or lost due to genetic mutation, infectious disease, chemical ototoxicity, noise and other factors, causing permanent sensorineural deafness. Regeneration of hair cells is a basic pre-requisite for recovery of hearing in deaf animals. The inner ear stem cells in the organ of Corti and vestibular utricle are the most ideal precursors for regeneration of inner ear hair cells. This review highlights some recent findings concerning the proliferation and differentiation of inner ear stem cells. The differentiation of inner ear stem cells into hair cells involves a series of signaling pathways and regulatory factors. This paper offers a comprehensive analysis of the related studies.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Células-Tronco
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Transdução de Sinais
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Diferenciação Celular
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Células Ciliadas da Ampola
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Orelha Interna
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article