Your browser doesn't support javascript.
loading
In vitro and in vivo activities of tigecycline-colistin combination therapies against carbapenem-resistant Enterobacteriaceae.
Betts, Jonathan W; Phee, Lynette M; Hornsey, Michael; Woodford, Neil; Wareham, David W.
Afiliação
  • Betts JW; Antimicrobial Research Group, Blizard Institute, Queen Mary University of London, London, United Kingdom.
  • Phee LM; Antimicrobial Research Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Division of Infection, Barts Health NHS Trust, London, United Kingdom.
  • Hornsey M; Department of Life Sciences, University of Roehampton, London, United Kingdom.
  • Woodford N; Antimicrobial Research Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Antimicrobial Resistance Healthcare Associated Infections Reference Unit, Public Health England, Colindale, London, United Kingdom.
  • Wareham DW; Antimicrobial Research Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Division of Infection, Barts Health NHS Trust, London, United Kingdom d.w.wareham@qmul.ac.uk.
Antimicrob Agents Chemother ; 58(6): 3541-6, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24687491
ABSTRACT
We assessed the activity of tigecycline (TGC) combined with colistin (COL) against carbapenem-resistant enterobacteria. Synergy occurred in vitro against the majority of isolates, with the exception of Serratia marcescens. In a simple animal model (Galleria mellonella), TGC-COL was superior (P < 0.01) in treating Escherichia coli, Klebsiella pneumoniae, and Enterobacter infections, including those with TGC-COL resistance. Clinical studies are needed to determine whether TGC-COL regimens may be a viable option.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Enterobacteriaceae / Infecções por Enterobacteriaceae / Minociclina / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Enterobacteriaceae / Infecções por Enterobacteriaceae / Minociclina / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article