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Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.
Dekker, Simone E; Sillesen, Martin; Bambakidis, Ted; Andjelkovic, Anuska V; Jin, Guang; Liu, Baoling; Boer, Christa; Johansson, Pär I; Linzel, Durk; Halaweish, Ihab; Alam, Hasan B.
Afiliação
  • Dekker SE; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.
  • Sillesen M; Division of Trauma, Emergency Surgery And Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery, Copenhagen University Hospital, Hillerød, Denmark.
  • Bambakidis T; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.
  • Andjelkovic AV; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
  • Jin G; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.
  • Liu B; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.
  • Boer C; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.
  • Johansson PI; Capital Region Blood Bank, University of Copenhagen, Rigshospitalet, Denmark; Department of Surgery, University of Texas Medical School, Centre for Translational Injury Research (CeTIR), Houston, Texas.
  • Linzel D; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Emergency Medicine, VU University Medical Center, Amsterdam, the Netherlands.
  • Halaweish I; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.
  • Alam HB; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan. Electronic address: alamh@med.umich.edu.
J Surg Res ; 190(1): 312-8, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24694719
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Choque Hemorrágico / Lesões Encefálicas / Ativação Plaquetária / Ácido Valproico / Inibidores de Histona Desacetilases Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Choque Hemorrágico / Lesões Encefálicas / Ativação Plaquetária / Ácido Valproico / Inibidores de Histona Desacetilases Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article