A rapid synthesis of 4-oxazolidinones: total synthesis of synoxazolidinones A and B.
Angew Chem Int Ed Engl
; 53(21): 5401-4, 2014 May 19.
Article
em En
| MEDLINE
| ID: mdl-24711268
ABSTRACT
A five-step total synthesis of the marine natural product synoxazolidinoneâ
A was achieved through a diastereoselective imine acylation/cyclization cascade. Synoxazolidinone B and a series of analogues were also prepared to explore the potential of these 4-oxazolidinone natural products as antimicrobial agents. These studies confirmed the importance of the chlorine substituent for antimicrobial activity and revealed simplified dichloro derivatives that are equally potent against several bacterial strains.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Guanidina
/
Oxazolidinonas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article