Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death.

Jashari, Ahmed; Imeri, Faik; Ballazhi, Lulzime; Shabani, Agim; Mikhova, Bozhana; Dräger, Gerald; Popovski, Emil; Huwiler, Andrea

Jashari, Ahmed; Imeri, Faik; Ballazhi, Lulzime; Shabani, Agim; Mikhova, Bozhana; Dräger, Gerald; Popovski, Emil; Huwiler, Andrea.

Afiliação

Jashari A; Group of Chemistry, Faculty of Natural Sciences & Mathematics, State University of Tetova, 1200 Tetova, Macedonia.
Imeri F; Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010 Bern, Switzerland.
Ballazhi L; Group of Chemistry, Faculty of Natural Sciences & Mathematics, State University of Tetova, 1200 Tetova, Macedonia; Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010 Bern, Switzerland.
Shabani A; Group of Chemistry, Faculty of Natural Sciences & Mathematics, State University of Tetova, 1200 Tetova, Macedonia.
Mikhova B; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Build. 9, 1113 Sofia, Bulgaria.
Dräger G; Institute of Organic Chemistry, Leibniz Universität Hannover, D-30167 Hannover, Germany.
Popovski E; Institute of Chemistry, Faculty of Natural Sciences & Mathematics, Ss. Cyril & Methodius University, PO Box 162, 1000 Skopje, Macedonia.
Huwiler A; Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010 Bern, Switzerland. Electronic address: Huwiler@pki.unibe.ch.

Bioorg Med Chem ; 22(9): 2655-61, 2014 May 01.

Article em En | MEDLINE | ID: mdl-24721833

Assuntos

Antineoplásicos/síntese química; Cumarínicos/química; Isoxazóis/química; Tiazóis/química; 4-Hidroxicumarinas/química; 4-Hidroxicumarinas/toxicidade; Antineoplásicos/química; Antineoplásicos/toxicidade; Apoptose/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Cumarínicos/síntese química; Cumarínicos/toxicidade; Humanos; Células MCF-7; Poli(ADP-Ribose) Polimerases/metabolismo; Células U937

Palavras-chave

Akt; Apoptosis; Cancer cells; Chromandiones; PARP-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Cumarínicos / Isoxazóis / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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