Five withanolides from the leaves of Datura metel L. and their inhibitory effects on nitric oxide production.
Molecules
; 19(4): 4548-59, 2014 Apr 11.
Article
em En
| MEDLINE
| ID: mdl-24731984
ABSTRACT
Four new withanolides named dmetelins A-D (compounds 1-4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 µM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Folhas de Planta
/
Vitanolídeos
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Datura metel
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Anti-Inflamatórios
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article