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Enantioselective construction of [6,5,6]-carbocyclic systems by organo/metal-catalyzed sequential reactions.
Wu, Xiang; Li, Ming-Li; Chen, Dian-Feng; Chen, Shu-Sen.
Afiliação
  • Wu X; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
J Org Chem ; 79(10): 4743-50, 2014 May 16.
Article em En | MEDLINE | ID: mdl-24742320
An efficient strategy for the enantioselective construction of [6,5,6]-carbocyclic compounds has been established via one-pot reaction of (E)-4-(2-ethynylphenyl)but-3-en-2-ones with maleimide sequentially catalyzed by cinchona alkaloid-based primary amine and gold complex (Ph3PAuNTf2). This methodology provided a facile approach to access the [6,5,6]-tricyclic skeleton in fairly good yield and with perfect enantioselectivities (98% to >99% ee).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Butanonas / Alcaloides de Cinchona / Aminas / Ouro / Maleimidas / Metais Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Butanonas / Alcaloides de Cinchona / Aminas / Ouro / Maleimidas / Metais Idioma: En Ano de publicação: 2014 Tipo de documento: Article