A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies.

Spaggiari, Dany; Geiser, Laurent; Daali, Youssef; Rudaz, Serge

Spaggiari, Dany; Geiser, Laurent; Daali, Youssef; Rudaz, Serge.

Afiliação

Spaggiari D; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Geiser L; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Daali Y; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland.
Rudaz S; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland. Electronic address: serge.rudaz@unige.ch.

J Pharm Biomed Anal ; 101: 221-37, 2014 Dec.

Article em En | MEDLINE | ID: mdl-24746851

Assuntos

Sistema Enzimático do Citocromo P-450/metabolismo; Cromatografia Líquida/métodos; Humanos; Espectrometria de Massas/métodos; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Especificidade por Substrato

Palavras-chave

CYP phenotyping; Cocktail; Drugdrug interactions; Human liver microsomes; In vitro methodology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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