A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes.
J Exp Med
; 170(3): 1051-6, 1989 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-2475569
A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Fragmentos de Peptídeos
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Proteínas Virais
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Linfócitos T Citotóxicos
/
Antígenos de Histocompatibilidade Classe I
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Proteínas do Core Viral
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Proteínas de Ligação a RNA
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Epitopos
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Nucleoproteínas
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article