Immunostimulatory effects of polysaccharides isolated from Makgeolli (traditional Korean rice wine).
Molecules
; 19(4): 5266-77, 2014 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-24762965
ABSTRACT
Makgeolli is a traditional Korean rice wine, reported to have various biological functions. In this study, the immunostimulatory activity of a polysaccharide from makgeolli (PSM) was investigated. The polysaccharide fraction was isolated from makgeolli by hot water extraction, ethanol precipitation, dialysis, and lyophilization. The major constituents in PSM were neutral sugars (87.3%). PSM was composed of five different sugars, glucose, mannose, galactose, xylose, and arabinose. In normal mice, PSM treatment increased the spleen index (p<0.05) as well as splenocyte proliferation (p<0.05) in combination with concanavalin A or lipopolysaccharide. The immunostimulatory activities of PSM were also examined in cyclophosphamide (CY)-induced immunosuppressed mice. Mice treated with PSM exhibited increased splenocyte proliferation (p<0.05), natural killer cell activity, and white blood cell counts (p<0.01) compared with immunosuppressed mice. These results indicate that PSM can enhance immune function in normal mice and CY-induced immunosuppressed mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Baço
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Vinho
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Imunidade Inata
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Fatores Imunológicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article