[Correlation study between ischemic stroke and polymorphism of human leucocyte antigen gene].

ABSTRACT

OBJECTIVE: To explore the correlation between ischemic stroke (IS) and the polymorphism of human leucocyte antigen (HLA) gene. METHODS: Antigen, allele, haplotype of HLA-A, B, C, DRB1, DQB1 in 94 IS patients and 503 healthy controls were detected by PCR-SBT. RESULTS: (1) There were 11 antigens, 17 alleles in HLA-A locus, 20 antigens, 34 alleles in HLA-B locus, 11 antigens, 16 alleles in HLA-C locus, 13 antigens, 26 alleles in HLA-DRB1 locus, 5 antigens, 13 alleles in HLA- DQB1 locus in IS group.(2) The allelic frequency of HLA-A*31 01 (P = 0.016 9, RR = 2.827) , HLA-B* 37 01 (P = 0.006 6, RR = 4.613) and HLA-DRB1*11 06 (P = 0.000 2, RR = 37.981) in the IS patients was higher than that in healthy controls.(3) The haplotypic frequency of HLA-DRB1*11 06-DQB1*03 01 (P = 0.001, RR = 38.52) in the IS patients was higher than that in healthy controls. CONCLUSION: The susceptibility association of HLA-B*37 01, HLA-DRB1*11 06 and HLA-DRB1*11 06-DQB1*03 01 with IS and HLA gene play a genetic role in the occurrence of.