The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2).

Nayak, Lalitha; Shi, Hong; Atkins, G Brandon; Lin, Zhiyong; Schmaier, Alvin H; Jain, Mukesh K

Nayak, Lalitha; Shi, Hong; Atkins, G Brandon; Lin, Zhiyong; Schmaier, Alvin H; Jain, Mukesh K.

Afiliação

Nayak L; Division of Hematology and Oncology, and Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Shi H; Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Atkins GB; Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Lin Z; Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Schmaier AH; Division of Hematology and Oncology, and.
Jain MK; Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.

Blood ; 123(24): 3828-31, 2014 Jun 12.

Article em En | MEDLINE | ID: mdl-24771858

Assuntos

Ácidos Borônicos/farmacologia; Trombose das Artérias Carótidas/prevenção & controle; Citoproteção/genética; Fatores de Transcrição Kruppel-Like/fisiologia; Pirazinas/farmacologia; Animais; Bortezomib; Trombose das Artérias Carótidas/sangue; Trombose das Artérias Carótidas/genética; Trombose das Artérias Carótidas/patologia; Células Cultivadas; Oclusão Coronária/genética; Oclusão Coronária/patologia; Oclusão Coronária/prevenção & controle; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Fatores de Transcrição Kruppel-Like/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Tempo de Coagulação do Sangue Total

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Ácidos Borônicos / Trombose das Artérias Carótidas / Citoproteção / Fatores de Transcrição Kruppel-Like Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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