[Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis].
Zhejiang Da Xue Xue Bao Yi Xue Ban
; 43(2): 145-9, 2014 03.
Article
em Zh
| MEDLINE
| ID: mdl-24782368
ABSTRACT
OBJECTIVE:
To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.METHODS:
An uncoated fused silica capillary (50 µm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-ß-cyclodextrin(pH 3.5).RESULTS:
Linear range was 2.00-80.00 µg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.CONCLUSION:
The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Carbamatos
/
Eletroforese Capilar
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article