Synthesis of new 5-substituted hydantoins and symmetrical twin-drug type hydantoin derivatives.
Chem Pharm Bull (Tokyo)
; 62(5): 429-38, 2014.
Article
em En
| MEDLINE
| ID: mdl-24789925
ABSTRACT
In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a-c to 5-aminomethyl-substituted hydantoins 5-10 or to 5-amino-5-methyl-disubstituted hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidantoínas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article