Hypoxia-induced mitogenic factor (FIZZ1/RELM&#945;) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension.

Yamaji-Kegan, Kazuyo; Takimoto, Eiki; Zhang, Ailan; Weiner, Noah C; Meuchel, Lucas W; Berger, Alan E; Cheadle, Chris; Johns, Roger A

Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension.

Yamaji-Kegan, Kazuyo; Takimoto, Eiki; Zhang, Ailan; Weiner, Noah C; Meuchel, Lucas W; Berger, Alan E; Cheadle, Chris; Johns, Roger A.

Afiliação

Yamaji-Kegan K; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland; kkegan1@jhmi.edu.
Takimoto E; Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland;
Zhang A; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland;
Weiner NC; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland;
Meuchel LW; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland;
Berger AE; Divison of Allergy and Clinical Immunology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
Cheadle C; Divison of Allergy and Clinical Immunology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
Johns RA; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland;

Am J Physiol Lung Cell Mol Physiol ; 306(12): L1090-103, 2014 Jun 15.

Article em En | MEDLINE | ID: mdl-24793164

Assuntos

Apoptose/fisiologia; Células Endoteliais/metabolismo; Hipertensão Pulmonar/metabolismo; Hipóxia/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Interleucina-4/metabolismo; Animais; Proliferação de Células; Modelos Animais de Doenças; Células Endoteliais/citologia; Hipertensão Pulmonar/patologia; Interleucina-4/genética; Pulmão/metabolismo; Pulmão/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pneumonia/metabolismo; Pneumonia/patologia

Palavras-chave

T-helper type 2 inflammation; endothelial apoptosis; human resistin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-4 / Apoptose / Peptídeos e Proteínas de Sinalização Intercelular / Células Endoteliais / Hipertensão Pulmonar / Hipóxia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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