An enantioselective Diels-Alder reaction of 1,2-dihydropyridines with α-acyloxyacroleins catalyzed by a chiral primary ammonium salt.
Chem Commun (Camb)
; 50(48): 6357-60, 2014 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-24800831
ABSTRACT
The first enantioselective Diels-Alder reaction of 1,2-dihydropyridines with α-acyloxyacroleins catalyzed by a chiral primary ammonium salt has been developed and it offers more efficient routes to key synthetic intermediates of alkaloids, for which the direct preparations were unavailable before. The asymmetric induction can be understood through the optimized geometry of an iminium salt aqua complex derived from the catalyst and the dienophile.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acroleína
/
Di-Hidropiridinas
/
Alcaloides
/
Compostos de Amônio Quaternário
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article