In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.

Han, Yong-Long; Li, Dan; Yang, Quan-Jun; Zhou, Zhi-Yong; Liu, Li-Ya; Li, Bin; Lu, Jin; Guo, Cheng

Han, Yong-Long; Li, Dan; Yang, Quan-Jun; Zhou, Zhi-Yong; Liu, Li-Ya; Li, Bin; Lu, Jin; Guo, Cheng.

Afiliação

Han YL; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Li D; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Yang QJ; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Zhou ZY; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Liu LY; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Li B; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Lu J; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
Guo C; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, China. guoc66@gmail.com.

Molecules ; 19(5): 5748-60, 2014 May 05.

Article em En | MEDLINE | ID: mdl-24802986

Assuntos

Apigenina/administração & dosagem; Inibidores das Enzimas do Citocromo P-450/administração & dosagem; Sistema Enzimático do Citocromo P-450/biossíntese; Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos; Glucuronatos/administração & dosagem; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/biossíntese; Animais; Hidrocarboneto de Aril Hidroxilases/biossíntese; Citocromo P-450 CYP1A2/biossíntese; Citocromo P-450 CYP2D6/biossíntese; Citocromo P-450 CYP3A/biossíntese; Sistema Enzimático do Citocromo P-450/genética; Família 2 do Citocromo P450; Humanos; Ratos; Esteroide 16-alfa-Hidroxilase/biossíntese

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Sistema Enzimático do Citocromo P-450 / Apigenina / Inibidores das Enzimas do Citocromo P-450 / Glucuronatos Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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