Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala.
Cancer Lett
; 351(1): 59-63, 2014 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-24814393
ABSTRACT
Analysis of 327 consecutive cases at a pediatric referral hospital of Guatemala reveals that retinoblastoma accounts for 9.4% of all cancers and the estimated incidence is 7.0 cases/million children, higher than the United States or Europe. The number of familial cases is low, and there is a striking disparity in indigenous children due to late diagnosis, advanced disease, rapid progression and elevated mortality. Nine germline mutations in 18 patients were found; two known and five new mutations. Hypermethylation of RB1 was identified in 13% of the tumors. An early diagnosis program could identify cases at an earlier age and improve outcome of retinoblastoma in this diverse population.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
/
Neoplasias da Retina
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
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Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
America central
/
Guatemala
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article