Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.

Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine

Awuah, Emelia; Ma, Eric; Hoegl, Annabelle; Vong, Kenward; Habib, Eric; Auclair, Karine.

Afiliação

Awuah E; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.
Ma E; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.
Hoegl A; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.
Vong K; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.
Habib E; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.
Auclair K; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada. Electronic address: karine.auclair@mcgill.ca.

Bioorg Med Chem ; 22(12): 3083-90, 2014 Jun 15.

Article em En | MEDLINE | ID: mdl-24814884

Assuntos

Escherichia coli/enzimologia; Fosfotransferases (Aceptor do Grupo Álcool)/química; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Domínio Catalítico; Coenzima A/metabolismo; Modelos Moleculares; Ácido Pantotênico/análogos & derivados; Ácido Pantotênico/metabolismo; Estrutura Terciária de Proteína; Relação Estrutura-Atividade

Palavras-chave

Coenzyme A; Enzyme ligand; Inhibitor; Kinase; Structureactivity relationship; Substrate selectivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) / Escherichia coli Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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