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A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Sievert, Henning; Pällmann, Nora; Miller, Katharine K; Hermans-Borgmeyer, Irm; Venz, Simone; Sendoel, Ataman; Preukschas, Michael; Schweizer, Michaela; Boettcher, Steffen; Janiesch, P Christoph; Streichert, Thomas; Walther, Reinhard; Hengartner, Michael O; Manz, Markus G; Brümmendorf, Tim H; Bokemeyer, Carsten; Braig, Melanie; Hauber, Joachim; Duncan, Kent E; Balabanov, Stefan.
Afiliação
  • Sievert H; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany.
  • Pällmann N; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
  • Miller KK; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
  • Hermans-Borgmeyer I; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
  • Venz S; Department of Medical Biochemistry and Molecular Biology, University of Greifswald, 17475 Greifswald, Germany.
  • Sendoel A; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland. Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Preukschas M; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany.
  • Schweizer M; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
  • Boettcher S; Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Janiesch PC; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
  • Streichert T; Department of Clinical Chemistry, University Hospital of Cologne, 50924 Cologne, Germany.
  • Walther R; Department of Medical Biochemistry and Molecular Biology, University of Greifswald, 17475 Greifswald, Germany.
  • Hengartner MO; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
  • Manz MG; Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Brümmendorf TH; Clinic for Internal Medicine IV, Hematology and Oncology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany.
  • Bokemeyer C; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany.
  • Braig M; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany.
  • Hauber J; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
  • Duncan KE; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
  • Balabanov S; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany. Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland. stefan.balabanov@usz.ch.
Dis Model Mech ; 7(8): 963-76, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24832488
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Desenvolvimento Embrionário / Oxigenases de Função Mista / Lisina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Desenvolvimento Embrionário / Oxigenases de Função Mista / Lisina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article