Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis, Silke; Krappitz, Annabel; Krappitz, Matteus; Murphy, Jane E; Bertog, Marko; Krueger, Bettina; Nacken, Regina; Chung, Hyunjae; Hollenberg, Morley D; Knecht, Wolfgang; Bunnett, Nigel W; Korbmacher, Christoph

Haerteis, Silke; Krappitz, Annabel; Krappitz, Matteus; Murphy, Jane E; Bertog, Marko; Krueger, Bettina; Nacken, Regina; Chung, Hyunjae; Hollenberg, Morley D; Knecht, Wolfgang; Bunnett, Nigel W; Korbmacher, Christoph.

Afiliação

Haerteis S; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Krappitz A; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Krappitz M; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Murphy JE; the UCSF Center for the Neurobiology of Digestive Diseases, Department of Surgery, University of California, San Francisco, California.
Bertog M; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Krueger B; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Nacken R; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany.
Chung H; the Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Hollenberg MD; the Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Knecht W; Bioscience, CVGI iMed, AstraZeneca Research and Development, 43181 Mölndal, Sweden.
Bunnett NW; the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, and the Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3010, Australia.
Korbmacher C; From the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstrasse 6, 91054 Erlangen, Germany, christoph.korbmacher@fau.de.

J Biol Chem ; 289(27): 19067-78, 2014 Jul 04.

Article em En | MEDLINE | ID: mdl-24841206

Assuntos

Canais Epiteliais de Sódio/metabolismo; Proteólise; Tripsina/metabolismo; Sequência de Aminoácidos; Animais; Azetidinas/farmacologia; Benzilaminas/farmacologia; Sítios de Ligação; Células Epiteliais/metabolismo; Canais Epiteliais de Sódio/química; Canais Epiteliais de Sódio/genética; Espaço Extracelular/metabolismo; Humanos; Rim/metabolismo; Dados de Sequência Molecular; Mutação; Oócitos/metabolismo; Estrutura Terciária de Proteína; Proteólise/efeitos dos fármacos; Xenopus laevis/genética

Palavras-chave

Epithelial Sodium Channel (ENaC); Ion Channel; Oocyte; Protease; Proteolytic Channel Activation; Serine Protease; Trypsin; Trypsin IV; Two-electrode Voltage Clamp

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripsina / Canais Epiteliais de Sódio / Proteólise Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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