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Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.
Cheng, Sam X; Lightfoot, Yaíma L; Yang, Tao; Zadeh, Mojgan; Tang, Lieqi; Sahay, Bikash; Wang, Gary P; Owen, Jennifer L; Mohamadzadeh, Mansour.
Afiliação
  • Cheng SX; Division of Gastroenterology, Department of Pediatrics, University of Florida, Gainesville, FL 32607, USA.
  • Lightfoot YL; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Yang T; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Zadeh M; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Tang L; Division of Gastroenterology, Department of Pediatrics, University of Florida, Gainesville, FL 32607, USA.
  • Sahay B; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Wang GP; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Owen JL; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Mohamadzadeh M; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32608, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: m.zadeh@ufl.edu.
FEBS Lett ; 588(22): 4158-66, 2014 Nov 17.
Article em En | MEDLINE | ID: mdl-24842610
ABSTRACT
The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Detecção de Cálcio / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Detecção de Cálcio / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article