Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.
FEBS Lett
; 588(22): 4158-66, 2014 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-24842610
ABSTRACT
The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Detecção de Cálcio
/
Mucosa Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article