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Intramuscular administration of paliperidone palmitate extended-release injectable microsuspension induces a subclinical inflammatory reaction modulating the pharmacokinetics in rats.
Darville, Nicolas; van Heerden, Marjolein; Vynckier, An; De Meulder, Marc; Sterkens, Patrick; Annaert, Pieter; Van den Mooter, Guy.
Afiliação
  • Darville N; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven 3000, Belgium.
  • van Heerden M; Drug Safety Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV.
  • Vynckier A; Drug Safety Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV.
  • De Meulder M; Drug Safety Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV.
  • Sterkens P; Drug Safety Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV.
  • Annaert P; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven 3000, Belgium.
  • Van den Mooter G; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven 3000, Belgium. Electronic address: Guy.VandenMooter@pharm.kuleuven.be.
J Pharm Sci ; 103(7): 2072-2087, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24845884
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitatos / Pró-Fármacos / Músculo Esquelético / Inflamação / Isoxazóis / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitatos / Pró-Fármacos / Músculo Esquelético / Inflamação / Isoxazóis / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article